微解读

创建自己的解读项目, 并与 WeGene 的众多用户分享
微解读分为专业版、普通版和专题共三类。
专业版微解读为社区中的生物信息开发者所创建,提供了较为复杂的基因数据解读和分析项目。
普通版微解读为的广大用户创建,反映了您的某个基因位点与性状的关系,只支持单位点影响的研究。
专题则是对某一特定问题的项目总集。
创建项目的位点须在微基因原始数据库中。
如果这些都不能满足您的需求,我们还有完全开放的API等着你。
*微解读内容均为用户创建,微基因不对解读内容负责。

Pro 眼睛颜色的预测

荷兰的科学家们于2011年发表了一篇文章,介绍其开发的IrisPlex系统可用于眼睛颜色的预测。他们对多个人种进行了大量实验后,开发了该工具用于对眼睛颜色的可能性预测,颜色主要分为蓝色(blue)、棕色(brown)以及介于两者之间的颜色(intermediate)。需要注意的是,该工具主要欧洲人为研究对象。


  • Yamol 发起人
  • 428 参与
  • 41 点赞
  • 3 评论

血型竟然还和抗雾霾能力有关?!

在刚刚过去的 2017 年美国心脏病协会大会期间,来自美国犹他州山间医疗中心心脏研究所的科学家报道,通过对该机构过去14年间的病患数据研究发现,在 PM2.5 暴露后,A 型、B 型、ABO 型的人发生急性心血管疾病事件的概率较 O 型的人更高。进一步分析发现,决定血型的 ABO 基因上的一个位点 rs687289 的基因型不同导致了这种差异。rs687289 为 GG 基因型的人(高概率为 O 型血)在PM 2.5下发生急性心血管事件的风险更低。


  • seacookie 发起人
  • 623 参与
  • 22 点赞
  • 4 评论

Pro 你会秃头吗?

综合位点的基因型计算男性相对于平均人群的秃头风险。 男性型秃发可能具有重大的心理社会影响,并且已经与前列腺癌和心血管疾病等不良健康结果有表型相关。该全基因组关联分析研究使用英国Biobank数据库的年龄在40-69岁之间的52,000名男性参与者,确定了超过250个与严重脱发相关的独立遗传基因位点。这次有了1000万个位点的扩展数据及之后,我们选取了15个位点用来预测男性相对于平均人群的秃头风险,它们都在该研究确定的250个位点的前20个影响最重要的位点中。 算出来的风险是相对于平均人群的,有高中低三个结果,分别表示你的基因型算出来的风险值处在平均人群分布的哪一块。 参考文献: Hagenaars SP, Hill WD, Harris SE, et al. Genetic prediction of male pattern baldness. PLoS Genet. 2017;13(2):e1006594.


  • 家顺 发起人
  • 7829 参与
  • 388 点赞
  • 33 评论

脂联素水平与乳腺癌之间的关系

一项包括 733 位乳腺癌患者的研究发现,rs2241766 与 rs1501299 的基因型突变组合会影响个体的脂联素(adiponectin)水平。同时,脂联素水平高的个体患乳腺癌的风险更低。中等脂联素水平的个体的患病率是高脂联素水平个体的 4.16 倍,低脂联素水平的患病率更高达 6.56 倍。


  • CAS9 发起人
  • 687 参与
  • 3 点赞
  • 2 评论

Pro 你是“痣多星”吗?

痣是一种最常见的良性皮肤肿瘤,是表皮、真皮内黑素细胞增多引起的皮肤表现,可以出现在皮肤的任何部位。中国传统文化对脸上的痣甚至有各种美称,如“美人痣”、“福痣”、“眉里藏珠”等。在欧美人中,平均每人大约全身有30颗痣,但是最多的能到400以上。 有研究发现,痣的多少和很多性状有关系。在一个1800人的研究中,英国科学家发现痣的多少和端粒长度有关,痣越多,端粒长度越长,预期寿命也越长。不过,痣同时也是黑色素瘤的重要风险因素,如果出现瘙痒、边缘不规则、颜色改变等情况,需要特别注意。 参考文献:Orlow I, Satagopan J M, Berwick M, et al. Genetic factors associated with naevus count and dermoscopic patterns: preliminary results from the Study of Nevi in Children (SONIC)[J]. British Journal of Dermatology, 2015, 172(4):1081-9.


  • yaoxt 发起人
  • 2631 参与
  • 179 点赞
  • 21 评论

你有多容易感到抑郁、悲伤、绝望和孤独呢?

BACKGROUND: Independent of temporal circumstances, some individuals have greater susceptibility to depressive affects, such as feelings of guilt, sadness, hopelessness, and loneliness. Identifying the genetic variants that contribute to these individual differences can point to biological pathways etiologically involved in psychiatric disorders. METHODS: Genome-wide association scans for the depression scale of the Revised NEO Personality Inventory in community-based samples from a genetically homogeneous area of Sardinia, Italy (n = 3972) and from the Baltimore Longitudinal Study of Aging in the United States (n = 839). RESULTS: Meta-analytic results for genotyped or imputed single nucleotide polymorphisms indicate that the strongest association signals for trait depression were found in RORA (rs12912233; p = 6 × 10⁻⁷), a gene involved in circadian rhythm. A plausible biological association was also found with single nucleotide polymorphisms within GRM8 (rs17864092; p = 5 × 10⁻⁶), a metabotropic receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. CONCLUSIONS: These findings suggest shared genetic basis underlying the continuum from personality traits to psychopathology.


  • wls 发起人
  • 2506 参与
  • 154 点赞
  • 17 评论

快来看一看你的皮肤保湿程度吧!

秋天到了,很多皮肤干燥的人又要苦恼了。然而,皮肤的保湿能力也是和基因相关的,有的小伙伴就是不容易干燥起皮。有研究通过比较不同人的经皮失水率(指透过表皮丢失的水分量,是评价皮肤屏障功能的重要指标之一),发现rs11103631在亚洲人中的频率和保湿能力显著相关。 来看下你的皮肤保湿程度吧!


  • shenzhen777 发起人
  • 4075 参与
  • 221 点赞
  • 17 评论

词汇发音能力

Candidate genes have been identified for both reading and language, but most of the heritable variance in these traits remains unexplained. Here, we report a genome-wide association meta-analysis of two large cohorts: population samples of Australian twins and siblings aged 12-25 years (n = 1177 from 538 families), and a younger cohort of children of the UK Avon Longitudinal Study of Parents and their Children (aged 8 and 9 years; maximum n = 5472). Suggestive association was indicated for reading measures and non-word repetition (NWR), with the greatest support found for single nucleotide polymorphisms (SNPs) in the pseudogene, ABCC13 (P = 7.34 × 10(-8)), and the gene, DAZAP1 (P = 1.32 × 10(-6)). Gene-based analyses showed significant association (P < 2.8 × 10(-6)) for reading and spelling with genes CD2L1, CDC2L2 and RCAN3 in two loci on chromosome 1. Some support was found for the same SNPs having effects on both reading skill and NWR, which is compatible with behavior genetic evidence for influences of reading acquisition on phonological-task performance. The results implicate novel candidates for study in additional cohorts for reading and language abilities.


  • wls 发起人
  • 3392 参与
  • 139 点赞
  • 17 评论

听力(语言性、listening)

Candidate genes have been identified for both reading and language, but most of the heritable variance in these traits remains unexplained. Here, we report a genome-wide association meta-analysis of two large cohorts: population samples of Australian twins and siblings aged 12-25 years (n = 1177 from 538 families), and a younger cohort of children of the UK Avon Longitudinal Study of Parents and their Children (aged 8 and 9 years; maximum n = 5472). Suggestive association was indicated for reading measures and non-word repetition (NWR), with the greatest support found for single nucleotide polymorphisms (SNPs) in the pseudogene, ABCC13 (P = 7.34 × 10(-8)), and the gene, DAZAP1 (P = 1.32 × 10(-6)). Gene-based analyses showed significant association (P < 2.8 × 10(-6)) for reading and spelling with genes CD2L1, CDC2L2 and RCAN3 in two loci on chromosome 1. Some support was found for the same SNPs having effects on both reading skill and NWR, which is compatible with behavior genetic evidence for influences of reading acquisition on phonological-task performance. The results implicate novel candidates for study in additional cohorts for reading and language abilities.


  • wls 发起人
  • 2940 参与
  • 132 点赞
  • 14 评论

听力(非语言性、hearing)

Hearing loss and individual differences in normal hearing both have a substantial genetic basis. Although many new genes contributing to deafness have been identified, very little is known about genes/variants modulating the normal range of hearing ability. To fill this gap, we performed a two-stage meta-analysis on hearing thresholds (tested at 0.25, 0.5, 1, 2, 4, 8 kHz) and on pure-tone averages (low-, medium- and high-frequency thresholds grouped) in several isolated populations from Italy and Central Asia (total N = 2636). Here, we detected two genome-wide significant loci close to PCDH20 and SLC28A3 (top hits: rs78043697, P = 4.71E-10 and rs7032430, P = 2.39E-09, respectively). For both loci, we sought replication in two independent cohorts: B58C from the UK (N = 5892) and FITSA from Finland (N = 270). Both loci were successfully replicated at a nominal level of significance (P < 0.05). In order to confirm our quantitative findings, we carried out RT-PCR and reported RNA-Seq data, which showed that both genes are expressed in mouse inner ear, especially in hair cells, further suggesting them as good candidates for modulatory genes in the auditory system. Sequencing data revealed no functional variants in the coding region of PCDH20 or SLC28A3, suggesting that variation in regulatory sequences may affect expression. Overall, these results contribute to a better understanding of the complex mechanisms underlying human hearing function.


  • wls 发起人
  • 1699 参与
  • 75 点赞
  • 4 评论

你容易长蛀牙吗?

OBJECTIVE: In this study, we investigated whether single nucleotide polymorphisms (SNPs) in DLX3 are associated with dental caries susceptibility in Japanese children. DESIGN: Genomic DNA of 201 Japanese children was extracted from buccal epithelial cells. The subjects were divided into two groups: 'low level' group with <10,000 colony forming units (CFU) of Streptococcus mutans/mL saliva (level 0) and 'high level' group with ≥ 10,000 CFU/mL (more than level 1). Each group was further divided according to decayed, missing, filled teeth (dmft) into low caries experience (dmft ≤2) and high caries experience (dmft ≥ 3). Seven SNPs in DLX3 were genotyped using TaqMan1® SNP Genotyping Assay. RESULTS: Statistical significant association was observed between DLX3 (rs2278163) and caries experience in 'high level Mutans streptococci' group. CONCLUSION: These findings suggest that rs2278163 SNP of DLX3 might be associated with dental caries susceptibility in Japanese children. T and C alleles of rs2278163 SNP may potentially be involved in caries susceptibility and caries protection respectively.


  • wls 发起人
  • 2305 参与
  • 187 点赞
  • 14 评论

Pro 算算你的K7b祖源成分

K7b是Dodecad祖源项目提供的祖源计算器之一。话不多说,赶紧算算你的K7b结果吧!


  • 西红柿码农 发起人
  • 9663 参与
  • 459 点赞
  • 114 评论

Pro K12b走你~

你们心心念念的K12b来了!今天小编我再来派发一个新的祖源计算器,有12个祖源成分呢,事情越来越复杂了~还有没有下一个我不告诉你!


  • 西红柿码农 发起人
  • 6451 参与
  • 153 点赞
  • 116 评论

Pro 快到E11的碗里来

在这个祭祖踏青的节日,小编来推出很多人都关心的E11了~E11计算器相比于之前的两个,对东亚人群做出了更友好的划分。快来看看你是哪个猩猩宝宝进化来的吧!


  • 西红柿码农 发起人
  • 7160 参与
  • 133 点赞
  • 133 评论

【你并不是学渣,只是没找到合适的方法】-最适合你的学习方法是什么?

你是否觉得现在的学习方式不适合你呢?


  • GlennGould 发起人
  • 2844 参与
  • 242 点赞
  • 8 评论

为你的拖延症找借口!你的拖延症有多严重?

美国最新心理研究发现,原来拖延症也和基因有关!


  • GlennGould 发起人
  • 2807 参与
  • 188 点赞
  • 19 评论

你儿童时期说话早吗?【该基因在自闭症患儿中多为GG】

rs2710102, a common SNP in the CNTNAP2 gene, was found to be significantly associated (p<0.028) with a delayed onset of speech, as measured by the age at which a child speaks their first words, in children with autism. This effect is primarily seen in males, perhaps correlated with the 4-5x overrepresentation of males with autism compared with females.[PMID 18179893OA-icon.png] The confirmatory Stage 2 study was performed on 304 independent parent-child trios. However, the risk allele and the degree to which speech is delayed per genotype is unclear as published and awaits clarification by the authors.[PMID 18179893OA-icon.png]


  • GlennGould 发起人
  • 2023 参与
  • 58 点赞
  • 17 评论

Dyslexia-阅读障碍:宝宝智商130,而且没有多动症,为啥成绩老不好?

有多个相互独立的关于阅读障碍的研究中,都发现了DCDC2基因所在的区域和阅读障碍有相关性。rs793862是DCDC2上的一个多态性位点, 在高加索人中,这个SNP的A碱基会使阅读障碍的风险升高。 在一个研究中, rs793862在更严重的诵读困难者的亚群中计算得到的风险值比在一般的阅读障碍的人群中更高。 AA型的相对风险,用一般的阅读障碍患者计算是3.15(95%置信区间为 1.30-7.66, p=0.011),用更严重的诵读困难的亚群计算的相对风险是 5.40(95%置信区间为 1.27-23.01, p=0.002)。


  • GlennGould 发起人
  • 2299 参与
  • 57 点赞
  • 12 评论

天(gene)注定系列之:数学能力

Mathematical ability is heritable, but few studies have directly investigated its molecular genetic basis. Here we aimed to identify specific genetic contributions to variation in mathematical ability. We carried out a genome wide association scan using pooled DNA in two groups of U.K. samples, based on end of secondary/high school national academic exam achievement: high (n = 419) versus low (n = 183) mathematical ability while controlling for their verbal ability. Significant differences in allele frequencies between these groups were searched for in 906,600 SNPs using the Affymetrix GeneChip Human Mapping version 6.0 array. After meeting a threshold of p<1.5×10(-5), 12 SNPs from the pooled association analysis were individually genotyped in 542 of the participants and analyzed to validate the initial associations (lowest p-value 1.14 ×10(-6)). In this analysis, one of the SNPs (rs789859) showed significant association after Bonferroni correction, and four (rs10873824, rs4144887, rs12130910 rs2809115) were nominally significant (lowest p-value 3.278 × 10(-4)). Three of the SNPs of interest are located within, or near to, known genes (FAM43A, SFT2D1, C14orf64). The SNP that showed the strongest association, rs789859, is located in a region on chromosome 3q29 that has been previously linked to learning difficulties and autism. rs789859 lies 1.3 kbp downstream of LSG1, and 700 bp upstream of FAM43A, mapping within the potential promoter/regulatory region of the latter. To our knowledge, this is only the second study to investigate the association of genetic variants with mathematical ability, and it highlights a number of interesting markers for future study.


  • wls 发起人
  • 3442 参与
  • 173 点赞
  • 34 评论

Pro 基因组纯合片段检测工具

连续性纯合片段 (runs of homozygosity, ROHs) 是指一类基因组中出现的连续不间断的纯合现象,表现为一段染色体区域缺乏杂合子。已有研究表明,较长的连续性片段可能会与各类疾病、癌症有一定相关性。 在生物学上,可以造成基因组连续性纯合的可能性有很多,比如来自婚配较为封闭的地区、父母 DNA 关系较近、单亲二倍体,甚至只是因为概率原因都有可能出现连续性纯合片段。 本工具利用全基因组芯片检测数据来寻找这样的片段。需要注意的是,由于 23andme 和 WeGene 的数据暂时不提供基因的拷贝数信息,因此,本工具找到的区域可能是连续性纯合片段,也可能是基因组有微缺失的片段。同时,查找的结果和不同芯片设计的位点、密度有一定关系,本结果只可做为参考。 # 2017.09.22 新增对 23andme V5 芯片的支持,修改了部分 no call 位点的 bug


  • yaoxt 发起人
  • 3245 参与
  • 85 点赞
  • 60 评论

Pro world9计算器:看看你是何许人也

今天的新计算器同样来自Dodecad项目,共9种成分,赶快来尝鲜吧~


  • 西红柿码农 发起人
  • 7851 参与
  • 261 点赞
  • 128 评论