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镰刀型细胞贫血症
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相关基因
HBB
位点：I3003137
位点：RS334
Salih NA, et al. Loss of balancing selection in the betaS globin locus. 2010
Savy M, et al. Haptoglobin and sickle cell polymorphisms and risk of active trachoma in Gambian children. 2010
Atkinson SH, et al. Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype. 2006
Ghansah A, et al. Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. 2012
Cardoso MA, et al. Underlying factors associated with anemia in Amazonian children: a population-based, cross-sectional study. 2012
Ayodo G, et al. Combining evidence of natural selection with association analysis increases power to detect malaria-resistance variants. 2007
Hanchard N, et al. Classical sickle beta-globin haplotypes exhibit a high degree of long-range haplotype similarity in African and Afro-Caribbean populations. 2007
Mangano VD, et al. Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations. 2009
Clark TG, et al. Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. 2009
Burghardt TP, et al. Myosin individualized: single nucleotide polymorphisms in energy transduction. 2010
Sambo MR, et al. Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children. 2010
Blackwell RQ, et al. Hemoglobin G Makassar: beta-6 Glu leads to Ala. 1970
Viprakasit V, et al. Hb G-Makassar [beta6(A3)Glu-->Ala; codon 6 (GAG-->GCG)]: molecular characterization, clinical, and hematological effects. 2002
纯合片段分析
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祖源平均脸
基因关系
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原始数据
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