zhengqiang zhengqiang - 勤奋学习 高原反应

高原反应检查哪些位点,准确性如何?

2014-11-25 • IP属地深圳
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4 个回复

xjp13 - 搞IT的BT人!
EPAS1基因的rs6756667和rs7583392
zhengqiang - 勤奋学习
SNPedia上面没有这两个点信息
大灰狼 - Don't worry, Be happy~
关于藏人EPAS1EGLN1受到选择适应高海拔的文章很多呀,nature,science各种灌水。

举几个例子:
Simonson T S, Yang Y, Huff C D, et al. Genetic evidence for high-altitude adaptation in Tibet[J]. Science, 2010, 329(5987): 72-75.

Yi X, Liang Y, Huerta-Sanchez E, et al. Sequencing of 50 human exomes reveals adaptation to high altitude[J]. Science, 2010, 329(5987): 75-78.
 
Beall C M, Cavalleri G L, Deng L, et al. Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders[J]. Proceedings of the National Academy of Sciences, 2010, 107(25): 11459-11464.

Xu S, Li S, Yang Y, et al. A genome-wide search for signals of high-altitude adaptation in Tibetans[J]. Molecular biology and evolution, 2011, 28(2): 1003-1011.

Peng Y, Yang Z, Zhang H, et al. Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas[J]. Molecular biology and evolution, 2011, 28(2): 1075-1081.

Lorenzo F R, Huff C, Myllymäki M, et al. A genetic mechanism for Tibetan high-altitude adaptation[J]. Nature genetics, 2014.

Huerta-Sánchez E, Jin X, Bianba Z, et al. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA[J]. Nature, 2014, 512(7513): 194-197. 
 
无畏的PTPRT基因 [禁言中]
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